Top Hotels Near Mayo Clinic Jacksonville

We checked thousands of reviews on and to find the best hotels for your stay
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Judy Hebron

Updated: 26 September 2024 · 4 min

Nestled on the northeastern coast of Florida, Jacksonville beckons visitors with its vibrant culture, stunning beaches, and world-class healthcare facilities. Among its numerous attractions, the renowned Mayo Clinic Jacksonville stands out as a beacon of medical excellence, drawing patients from near and far. For those seeking proximity and convenience, the abundance of hotels near Mayo Clinic Jacksonville offers unparalleled comfort and accessibility, catering to the diverse needs of patients, families, and medical professionals alike.

As you explore the charming streets of Jacksonville, each lined with unique eateries and boutiques, the significance of finding the perfect accommodation becomes paramount. Hotels near Mayo Clinic Jacksonville not only provide a restful retreat after a long day of appointments but also offer a sense of security and peace of mind to those undergoing medical treatment. From luxurious suites to cozy bed-and-breakfasts, these accommodations ensure that your stay is characterized by comfort, convenience, and unwavering hospitality.

Whether you're in Jacksonville for a medical consultation, a loved one's treatment, or simply to experience the city's coastal beauty, choosing the right accommodation near Mayo Clinic Jacksonville can significantly enhance your visit. With a plethora of options available, each offering unique amenities and services, finding the ideal hotel becomes a personalized journey tailored to your specific preferences and requirements. Embrace the tranquility and support that these hotels provide, allowing you to focus on what matters most during your time in beautiful Jacksonville.
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Our Top 7

(Sorted by rating & number of reviews)

1. Baymont By Wyndham Jacksonville
2. Hampton Inn Jacksonville
3. Holiday Inn Express & Suites Jacksonville, An Ihg Hotel
4. Best Western Jacksonville Inn
5. Blessings On State Bed & Breakfast Bed & Breakfast
6. Knights Inn Jacksonville
7. Super 8 By Wyndham Jacksonville

Top Luxury Hotels near Mayo Clinic Jacksonville

Check Availability

Jacksonville
Mar 08, 2026 - Mar 09, 2026

Baymont By Wyndham Jacksonville

1.5

Good

(2 Reviews)

+ 60 photos
Baymont By Wyndham Jacksonville presents a budget-friendly option for guests seeking a convenient and comfortable stay near Mayo Clinic Jacksonville. The hotel features well-appointed rooms, complimentary breakfast, and a range of amenities to ensure a pleasant and affordable lodging experience. Its proximity to the medical facility makes it a practical choice for those requiring cost-effective accommodation without compromising on quality or convenience.
Address: 1914 Southbrooke Road
Rating: Good 1.5 (2 Reviews)
Rooms: 62
Price: From 55$

Hampton Inn Jacksonville

8.1

Good

(73 Reviews)

+ 41 photos
Boasting a blend of modern design and Southern charm, Hampton Inn Jacksonville exudes luxury and sophistication, making it a top pick for discerning travelers near the Mayo Clinic. Guests can enjoy a range of amenities, including an outdoor pool, fitness center, and complimentary hot breakfast, ensuring a lavish experience from check-in to check-out. Located just a short drive from the clinic, this hotel offers convenience and opulence in one exquisite package.
Address: 1725 West Morton Avenue
Rating: Good 8.1 (73 Reviews)
Rooms: 65
Price: From 104$

Budget-Friendly Hotels near Mayo Clinic Jacksonville

In this section, we present a curated list of budget-friendly hotels near the Mayo Clinic Jacksonville, perfect for those seeking quality accommodation at an affordable rate without compromising on comfort or convenience. These hotels offer a cost-effective solution for patients, families, and visitors, ensuring a pleasant stay within a reasonable budget near the esteemed medical facility.

Holiday Inn Express & Suites Jacksonville, An Ihg Hotel

6.7

Good

(58 Reviews)

+ 92 photos
Holiday Inn Express & Suites Jacksonville is a family-friendly hotel located near the Mayo Clinic, providing comfortable accommodations and a host of amenities for guests of all ages. Families can enjoy spacious rooms, complimentary breakfast, a pool, and a fitness center, ensuring a pleasant and convenient stay during their time in Jacksonville. With its focus on family-centric services and a welcoming atmosphere, this hotel offers a nurturing environment for families near the clinic.
Address: 2501 Holliday Lane
Rating: Good 6.7 (58 Reviews)
Rooms: 69
Price: From 109$

Best Western Jacksonville Inn

8.4

Good

(227 Reviews)

+ 129 photos
With its elegant decor and upscale amenities, Best Western Jacksonville Inn stands out as a premier choice for those seeking luxury near Mayo Clinic Jacksonville. The hotel features spacious rooms, a fitness center, and complimentary breakfast, ensuring a lavish and relaxing stay for all guests. Its proximity to the clinic makes it an ideal choice for those requiring easy access to medical facilities without compromising on comfort.
Address: 1709 W Morton Avenue
Rating: Good 8.4 (227 Reviews)
Rooms: 56
Price: From 65$

Family-Friendly Hotels near Mayo Clinic Jacksonville

For families visiting or accompanying loved ones to the Mayo Clinic Jacksonville, selecting a family-friendly hotel is paramount. This section highlights accommodations that cater to the needs of families, offering spacious rooms, kid-friendly amenities, and convenient proximity to the medical facility for a stress-free and enjoyable stay.

Blessings On State Bed & Breakfast Bed & Breakfast

10.0

Good

(1 Reviews)

+ 35 photos
For a truly indulgent escape near Mayo Clinic Jacksonville & Breakfast provides a unique and intimate setting that combines luxury with personalized service. Each suite is tastefully appointed with elegant decor and modern conveniences, promising a serene retreat for guests seeking comfort and tranquility. With its proximity to the clinic and a warm, welcoming atmosphere, this bed and breakfast offers a luxurious stay tailored to the needs of those visiting the medical facility.
Address: 1109 West State Street
Rating: Good 10.0 (1 Reviews)
Rooms: 12
Price: From 269$

Knights Inn Jacksonville

5.8

Good

(33 Reviews)

+ 17 photos
Knights Inn Jacksonville offers a budget-friendly lodging solution near Mayo Clinic Jacksonville, providing guests with a comfortable stay at an affordable price point. With its convenient location, cozy rooms, and essential amenities, this hotel caters to visitors looking for cost-effective accommodation options near the medical facility. Whether you're in town for medical purposes or simply exploring Jacksonville on a budget, Knights Inn Jacksonville presents a practical and welcoming choice for your stay.
Address: 1111 East Morton Ave
Rating: Good 5.8 (33 Reviews)
Rooms: 39
Price: From 77$

Pet-Friendly Hotels near Mayo Clinic Jacksonville

For pet owners traveling to the Mayo Clinic Jacksonville, finding pet-friendly accommodations is essential. This section highlights hotels that welcome furry companions, providing a comfortable stay for both guests and their beloved pets near the medical facility.

Super 8 By Wyndham Jacksonville

7.6

Good

(90 Reviews)

+ 41 photos
Super 8 By Wyndham Jacksonville provides a comfortable and affordable lodging option near the Mayo Clinic, catering to budget-conscious travelers without sacrificing comfort or essential amenities. Guests can enjoy cozy rooms, complimentary breakfast, and a convenient location, making it an ideal choice for those seeking affordable accommodation near the clinic. With its commitment to affordability and quality service, this hotel offers a practical yet comfortable stay for visitors to Jacksonville.
Address: 1003 W Morton Ave
Rating: Good 7.6 (90 Reviews)
Rooms: 43
Price: From 62$